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36% of those infected with covid and without vaccination no longer have antibodies a year later & More Latest News Here


  • A study by the Barcelona Institute for Global Health confirms that hybrid immunity (vaccine plus contagion) is the greatest and longest lasting

The 36% of the people of between 43 and 72 years that they got infected from covid-19 a year ago and they were not vaccinated Already they have no detectable antibodies. It occurs especially in those over 60 years of age and smokers. A study led by Barcelona Institute for Global Health (ISGlobal), promoted by the La Caixa Foundation, on the seroprevalence in the population of Catalonia underline the need to be vaccinated despite having been infected and confirms that, in these cases, hybrid immunity (vaccination plus infection) is larger and more durable. The research, in which the German Trias i Pujol Institute (IGTP) has collaborated, with the support of the Daniel Bravo Andreu Private Foundation (FPDBA), has been published in the journal ‘BMC Medicine’.

To analyze the importance of covid-19 vaccine must take into account the “diversity” of the population. “To the people healthy adults, their natural immunity lasts longer. However, in the elderly people, with disabilities or some comorbidity, we see that the loss of antibodies after being infected naturally occurs in one out of three. That’s why it’s important here influence vaccination explains to this newspaper Charlotte Dobano, head of the immunology group at ISGlobal.

Both the infection as the vaccination against SARS-CoV-2 contribute to building the immunity of a population against the virus. This is important information for deciding when and to whom give booster shots. Seroepidemiological studies help to assess immunity in certain population groups. Most of the studies after vaccination against covid-19 focused on specific groups such as health personnel and they did not distinguish between people with or without previous infection. The ISGlobal study tracked the levels and types of antibodies from 1,076 people between 43 and 72 years old in two phases: the first between June and November 2020, and the second between May and July 2021.

three conclusions

The results yielded three main conclusions. The first is that in the 36% of people infected but not vaccinated antibodies were no longer detectable one year after infection, especially in people over 60 years of age and smokers. “Particularly, those over 60 years of age and with comorbidities and smokers – tobacco is another risk factor – it is easier for them to lose the antibodies induced by the infection, and that is why they must be vaccinated with booster doses,” explains Dobaño. .

The second conclusion is that, in the people with previous infection, vaccination produced levels of antibodies considerably higher than in people without previous infection. “Our data underscore the importance of vaccinating people, even if they have been previously infected, and confirm that hybrid immunity is superior and longer lasting. This means that people who have been vaccinated but have not passed the infection would need a booster sooner than those who have, “he notes, for his part, Marianna Karachaloufirst author of the study together with Gemma Moncunill

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The third conclusion is that the factor most strongly associated with the level of antibodies is the type of vaccine. modern was the one that generated the most antibodies. In addition, they also seem to influence other factors: the People over 60 years or with Mental illness had lower antibody levels after vaccination. “The association between mental health and antibody response requires further investigation, but it is known that people with disorders such as depression, chronic stress or schizophrenia have a lower response to vaccination in general,” says Dobaño.

However, experts still do not know “what is the minimum number of antibodies necessary” to be protected. “Yes, it is known in other vaccines, such as hepatitis B. But, in covid-19, this is still a matter of investigation,” concludes the ISGlobal researcher.

36% of those infected with covid and without vaccination no longer have antibodies a year later
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