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A third of those infected with covid and who were not vaccinated, without antibodies a year later & More Latest News Here

 

A prospective study of seroprevalence in the population of Catalonia underlines the need to be vaccinated despite having been infected and confirms that hybrid immunity (vaccination plus infection) is greater and more durable.

In this sense, the research -co-led by the Barcelona Institute for Global Health (ISGlobal) and the German Trias i Pujol Institute (IGTP), with the support of the Daniel Bravo Andreu Private Foundation- ensures that 36% of infected people but not vaccinated, antibodies were no longer detectable one year after infection.

Hybrid immunity (vaccination plus infection), greater and longer lasting

Both infection and vaccination against SARS-CoV-2 contribute to building a population’s immunity against the virus – an important piece of information for deciding when and to whom to apply booster vaccines. The easiest strategy to evaluate said immunity is to carry out seroepidemiological studies (that is, to quantify virus-specific antibodies in a certain population group), although immunity against a pathogen goes beyond antibodies.

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“Most of the serological studies carried out after vaccination against Covid-19 focused on specific groups such as health personnel, they did not distinguish between people with or without previous infection, or they did not have clinical and immunological data of said infection”, explains Manolis Kogevinas , ISGlobal researcher and senior co-author of the study together with fellow ISGlobal researcher Carlota Dobaño.

vaccine

More than 1,000 people have been included in the study

LV / Xavier Cervera

In this study, published in the journal BMC Medicine, the research team carried out a measurement in a population cohort of Catalonia six months after the start of vaccination to monitor the level and type of antibodies against five viral antigens: the entire Spike (S) protein, the receptor-binding domain RBD, the S2 fragment, the entire Nucleocapsid (N) protein, or the N-terminal fragment.

They also used information obtained from a questionnaire and from health records to identify factors that potentially determine the magnitude and duration of response in unvaccinated, vaccinated, or vaccinated and infected persons (1076 persons included in the analysis, aged 43 to 72). year old).

another conclusion

Vaccination induced significantly higher antibody levels in people with previous infection

In addition to detecting that in 36% of people infected but not vaccinated antibodies were no longer detected one year after infection, especially in people over 60 years of age and smokers, the researchers reached two more conclusions.

First, in previously infected people, vaccination induced considerably higher antibody levels than in previously uninfected people. These levels were strongly associated with the magnitude of the response during infection.

The data underscores the importance of vaccinating people, even if they have been previously infected.”

Marianna KarachalouFirst author of the study

“Our data underscores the importance of vaccinating people, even if they have been previously infected, and confirms that hybrid immunity is superior and longer-lasting,” says Marianna Karachaliou, first author of the study together with Gemma Moncunill. “This means that people vaccinated but that have not passed the infection would need a booster before those that have, “he adds.

The second, that the factor most strongly associated with the level of antibodies is the type of vaccine. In this sense, Moderna’s Spikevax was the one that generated the most antibodies.

The factor most strongly associated with the level of antibodies is the type of vaccine

In addition, other factors also seem to play a role: people over 60 years of age or with mental illness had lower levels of antibodies after vaccination. “The association between mental health and antibody response requires further investigation, but it is known that people with disorders such as depression, chronic stress or schizophrenia have a lower response to vaccination in general,” explains Dobaño.

Among vaccinated people, only 2.1% had no antibodies at the time of testing and approximately 1% had a post-vaccination infection. “However, it is necessary to point out that this study was done before the omicron variant became dominant,” Kogevinas concludes.

A third of those infected with covid and who were not vaccinated, without antibodies a year later
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