adplus-dvertising
Hot Stories

Multiple sclerosis, new way to reduce neurological damage – Biotech & More Latest News Here

 

A new way has been found that could reduce the neurological damage of multiple sclerosis: it aims to regulate the altered metabolism of oligodentrocytes, the cells of the nervous system responsible for the production of myelin, the lipid sheath that surrounds the extensions of neurons favoring the transmission of nerve impulses. This was discovered by researchers from the State University of Milan, thanks to a study funded by the Italian Multiple Sclerosis Foundation (Fism) and published in the journal Cells.

The research group, led by Maria Pia Abbracchio, has been working for years to clarify the crucial role of the GPR17 receptor, which is found on the surface of oligodendrocyte precursors (Opc). This receptor, expressed in large quantities in immature cells, is turned off at some point in differentiation to allow the oligodentrocytes to mature and become capable of producing myelin. If the shutdown is not done properly and the receptor continues to be expressed at high levels, there is an inability to repair damage to myelin, a problem shared by several neurological diseases including multiple sclerosis.

To find out which molecular mechanisms are altered by the insane receptor, the researchers reproduced the physiological shutdown of GPR17 in a test tube, evaluating the consequences on the metabolic and lipid profile at the different stages of maturation of the precursors of the oligodentrocytes. They found that the shutdown of the receptor induces a powerful rearrangement of glucose metabolism that leads to an increase in extracellular levels of lactate (which is like fuel for neurons). In addition, changes in the levels of particularly abundant lipid molecules in myelin were observed.

According to the researchers, the use of drugs directed against GPR17 could counter the metabolic dysfunctions associated with demyelinating diseases such as multiple sclerosis. The same metabolic and energetic mechanisms regulated by GPR17 could become targets for improving wound repair in multiple sclerosis.

REPRODUCTION RESERVED © Copyright ANSA

Multiple sclerosis, new way to reduce neurological damage – Biotech
& Latest News Update

I have tried to give all kinds of news to all of you latest news today 2022 through this website and you are going to like all this news very much because all the news we always give in this news is always there. It is on trending topic and whatever the latest news was

it was always our effort to reach you that you keep getting the Electricity News, Degree News, Donate News, Bitcoin News, Trading News, Real Estate News, Gaming News, Trending News, Digital Marketing, Telecom News, Beauty News, Banking News, Travel News, Health News, Cryptocurrency News, Claim News latest news and you always keep getting the information of news through us for free and also tell you people. Give that whatever information related to other types of news will be

Multiple sclerosis, new way to reduce neurological damage – Biotech
& More Live News

All this news that I have made and shared for you people, you will like it very much and in it we keep bringing topics for you people like every time so that you keep getting news information like trending topics and you It is our goal to be able to get

all kinds of news without going through us so that we can reach you the latest and best news for free so that you can move ahead further by getting the information of that news together with you. Later on, we will continue

to give information about more today world news update types of latest news through posts on our website so that you always keep moving forward in that news and whatever kind of information will be there, it will definitely be conveyed to you people.

Multiple sclerosis, new way to reduce neurological damage – Biotech
& More News Today

All this news that I have brought up to you or will be the most different and best news that you people are not going to get anywhere, along with the information Trending News, Breaking News, Health News, Science News, Sports News, Entertainment News, Technology News, Business News, World News of this made available to all of you so that you are always connected with the news, stay ahead in the matter and keep getting today news all types of news for free till today so that you can get the news by getting it. Always take two steps forward

The Article Is In Italian🡽

Back to top button