The race for the top four continues at the end of the Premier League season, with the match between Manchester United and Chelsea at Old Trafford affecting Champions League qualification.
Currently, Man Utd are down to sixth place, six points off the top four after defeat by Arsenal last week.
After this loss, manager Ralf Rangnick all but confirmed his belief that the top four were out of his team’s each.
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Chelsea, meanwhile, sit in third place, but a bit of inconsistent form has the Blues looking over their shoulders.
Man Utd are suffering a bit of an injury crisis ahead of this one as Rangnick confirmed on Wednesday that six first-team players will miss out.
“Unfortunately Fred is not available yet, he tried to train yesterday but after training I had a long conversation with him and he told me he is still not fully fit, he is not 100 percent,” Rangnick told reporters .
“With a player like Fred who is always committed to giving his best, it doesn’t make sense with a muscle injury to play him too early because we would be taking the risk of him getting injured again and that’s something I do. Except from that Harry Maguire is not available tomorrow he has some problems with his knee not a big thing some numb in the knee he didn’t train yesterday and today.
“Paul (Pogba), of course, Fred, Edinson (Cavani), Luke Shaw (are all out) and Jadon (Sancho) are sick – he’s had tonsillitis since yesterday. He couldn’t train today and won’t be available in morning .”
David de Gea will start in goal behind a likely back four of Diogo Dalot, Victor Lindelof, Raphael Varane and Alex Telles.
Nemanja Matic and Scott McTominay should continue in midfield, with Anthony Elanga, Bruno Fernandes and Marcus Rashford forming the attacking trio behind Cristiano Ronaldo.
As for Chelsea, they have received positive news on the injury front as Reece James and Antonio Rudiger both completed training on Tuesday. James missed the West Ham game, while Rudiger has not played since the FA Cup semi-final win against Crystal Palace.
However, they will still be without Mateo Kovacic, Callum Hudson-Odoi and Ben Chilwell, while Andreas Christensen and Ross Barkley are ill and will be assessed closer to kick off.
Edouard Mendy starts in goal, with Rudiger coming back in central defense alongside Thiago Silva and Cesar Azpilicueta.
James will return to his wing-back position if he is fit, with Marcos Alonso on the opposite side.
With Kovacic still out, the central midfield pair of Jorginho and N’Golo Kante pick themselves.
Christian Pulisic scored the late winner against West Ham, allowing him to come on to replace Timo Werner, with Mason Mount and Kai Havertz retaining their places in the front three.
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